Endocrine Abstracts

Materials and methods: Included patients were divided into … groups: group 1 – 41 almost healthy person (control group), group 2 – 59 patients with prediabetes, group 3 – 41 patients with T2D, group 4 – 40 patients with T2D and CHD and group 5 – 88 patients with CHD. Activities of glutathione peroxidase (GP, mmol/min) and glutathione reductase (GR, mmol/min) and concentrations of reduced glutathione (GSH, mmol/l), oxidized glutathione (GSSG, mmol...

One of the key enzymes of antioxidant system is superoxide dismutase (SOD) that catalyses dismutation of superoxide anionic radical (O2−)l to molecular oxygen (O2) and hydrogen (H2O2). It was revealed that activity of SOD is decreased in patients with decompensated type 2 diabetes (T2D) but there is insufficient data about enzyme activity in compensated states and prediabetes.Purpose: To analys...

It is known that patients with prediabetes (impaired glucose tolerance and impaired fasting glucose) ant type 2 diabetes (T2D) have micro-and macrovascular complications. It may be assumed that vascular changes begin in the smallest vessels that leads to microcirculation abnormalities.Purpose: To estimate microcirculation abnormalities in patients with prediabetes and T2D and concomitant atherosclerosis.Materials and methods: One h...

Background: One of the basic genetic factors that impact on development of diabetic nephropathy is enhanced expression of vascular endothelial growth factor (VEGF).Objective: To study association between VEGF polymorphism +405 G/C and early stage of chronic kidney disease (CKD) in patients with impaired glycemic states.Materials and methods: 73 included patients were divided into three groups: group 1–26 patients with prediabe...

To determine the relationship between indicators of inflammation and the blood redox status of type 2 diabetic (T2DM) patients with and without coronary heart disease (CHD).Forty four patients with T2DM and CHD (group 1), 67 patients with T2DM without cardiovascular complications (group 2), 89 healthy subjects (group 3) were included in this study. Serum concentrations of IL6 and IL8 were determined by ELISA using commercial kits. Concentrations of thiob...

Myeloperoxidase (MPO), an enzyme of the innate immune system, exhibits pro-atherogenic effects and includes influence on oxidative damage to LDL- and HDL-cholesterol, and promotion of endothelial dysfunction.The aim: To investigate the disturbance of MPO in type 2 diabetic (T2D) patients depending on intensity of atherosclerosisMaterial and methods: We investigated 244 patients aged from 45 to 60 years (M±SD 54.0±4.63) in...

The glucose-dependent insulinotropic polypeptide receptor (GIPR) is a 7-transmembrane class B G-protein coupled receptor that mediates the incretin response after nutrient stimulation. Although mostly involved in metabolic disorders, in the last years an improper activation of the GIP/GIPR axis has been increasingly recognized in endocrine tumors, with a potential diagnostic and prognostic value. In Medullary Thyroid Cancer (MTC), a neuroendocrine tumor of the parafollicular C...

Introduction: Many studies have found that markers of oxidative stress (OS) are significantly increased in diabetes mellitus, but only a limited number of studies describe the disturbance of OS in pre-diabetes.Objective: To study the state of the glutathione system in patients with disorders of carbohydrate metabolism and concomitant diseases of the cardiovascular system (CVS).Materials and methods: 181 patients were included under...

IntroductionProspective and retrospective trials report the incidence of endocrine adverse events provoked by immune checkpoint inhibitors (ICI) up to 30%. PD-1/PDL inhibitors have a higher incidence of thyroid dysfunction: hypothyroidism 5%-14%, transient hyperthyroidism – 3%-5%.The aim of the study was to assess thyroid function in PD-1/PDL treated patients.Materials and methods6...

Background: GEP-NETS and PPGLs in pediatric patients are rare; however, recognition of these diseases has increased recently. 10–20% of pediatric patients with GEP-NETs and up to 47% of pediatric patients with PPGLs present with metastatic disease at diagnosis. The disease is often unresectable with poor prognosis, and very few non-surgical therapies are approved for these patients. Due to paucity of data surrounding treatments for pediatric patients with advanced GEP-NET...